Premium Pal GHK Peptide (Palmitoyl Tripeptide-1) – UK Research Grade

If your laboratory or formulation facility is looking to study extracellular matrix remodeling, Pal GHK offers an lipophilic messenger peptide derivative. Known chemically as Palmitoyl Tripeptide-1 (or Palmitoyl-Gly-His-Lys), the Pal GHK peptide combines the classic GHK copper-binding matrikine sequence with a palmitic acid fatty acid chain. This lipophilic modification increases skin membrane permeability and cellular lipophilicity compared to standard water-soluble GHK.

Whether investigating collagen synthesis induction, elastin matrix repair, or dermal fibroblast proliferation, our high-purity Pal GHK reference material provides certified batch consistency, analytical documentation, and fast domestic UK shipping.

Technical Specifications & Chemical Profile

Our reference-grade Pal GHK peptide (Palmitoyl Tripeptide-1) is synthesized under strict quality control standards:

Attribute	Analytical Specification
Product Name	Pal GHK / Palmitoyl GHK (Palmitoyl Tripeptide-1)
CAS Registry Number	147732-56-7
Sequence	Palmitoyl-Gly-His-Lys-OH
Molecular Formula	C₃₀H₅₄N₆O₅
Molecular Weight	578.80 g/mol
Purity Grade	≥98.0% (Verified via HPLC & Mass Spectrometry)
Physical Appearance	White to off-white lyophilized powder
Solubility Profile	Soluble in DMSO, Ethanol, and warm amphiphilic solvent bases
Storage (Unopened)	Store dry at -20°C (protected from moisture and direct light)

Mechanism of Action & Pal GHK Research Applications

In bio-cosmetic literature and tissue engineering studies, Pal GHK is categorized as a signal matrikine peptide that stimulates specific dermal regeneration pathways:

• Extracellular Matrix (ECM) Stimulation: Research demonstrates that Pal GHK acts on dermal fibroblasts to stimulate the synthesis of Collagen Type I, Collagen Type III, and glycosaminoglycans (GAGs) such as hyaluronic acid.

• Enhanced Skin Permeation: Standard GHK peptide possesses high water solubility, limiting passive lipid membrane penetration. Attaching a 16-carbon palmitic acid chain to form Pal GHK enhances lipid solubility, enabling deeper penetration into dermal layers in topical formulation models.

• Tissue Repair Signaling: As a fragment derived from collagen alpha-1 chains, Pal GHK peptide signals tissue degradation, prompting fibroblasts to initiate new structural protein synthesis to restore extracellular architecture.

Handling & Formulation Guidelines

To maintain peptide stability and prevent oxidation during experimental formulation:

1. Equilibration: Allow the Pal GHK peptide container to reach ambient room temperature prior to opening to prevent atmospheric condensation inside the vial.

2. Solubility & Dissolution: Pal GHK is hydrophobic due to the attached palmitoyl chain. Dissolve in an appropriate organic solvent (such as DMSO, propanediol, or ethanol) or blend into an emulsified oil phase at controlled temperatures (<40°C).

3. pH Sensitivity: Maintain formulation research models within a stable pH range of 4.5 to 6.5 to prevent hydrolysis of the tripeptide bond chain.

4. Storage: Keep raw powder stored sealed at -20°C. Store liquid formulation stock solutions refrigerated between 2°C and 8°C.

Frequently Asked Questions

What is the difference between GHK-Cu and Pal GHK peptide?

GHK-Cu is a water-soluble tripeptide complexed with copper ions. Pal GHK (Palmitoyl Tripeptide-1) is attached to a palmitic fatty acid chain to increase lipid solubility and transdermal penetration without needing a bound copper ion.

What is the recommended research concentration for Pal GHK?

In scientific formulation trials evaluating collagen stimulation, Pal GHK is typically tested at active concentration ranges between 1 ppm and 10 ppm (0.0001% to 0.001% active peptide concentration).

What documentation accompanies the Pal GHK peptide?

Every batch includes access to a lot-specific Certificate of Analysis (COA) displaying High-Performance Liquid Chromatography (HPLC) traces verifying ≥98% purity and Mass Spectrometry (MS) confirming the molecular mass of 578.80 g/mol.