Premium CJC 1295 w DAC Peptide (2mg) – UK Research Grade

If your facility is seeking to buy cjc 1295 w dac for endocrinological and growth hormone axis studies, our domestic inventory supplies high-purity cjc1295 with dac (Drug Affinity Complex). As a tetrasubstituted 29-amino acid peptide analogue of naturally occurring Growth Hormone Releasing Hormone (GHRH), this popular sequence within the cjc peptides family is designed to extend systemic half-life and stimulate continuous growth hormone (GH) secretion from the anterior pituitary gland.

By covalently bonding to endogenous serum albumin following administration, the Drug Affinity Complex (DAC) modification prevents rapid renal clearance and enzymatic degradation, increasing the biological half-life from 30 minutes to approximately 6 to 8 days. Whether conducting cell signaling, metabolic, or lean tissue preservation experiments, our reference-grade cjc peptides deliver ≥99% HPLC-certified chemical purity, complete batch documentation, and fast UK domestic dispatch.

Technical Specifications & Chemical Profile

Our reference-grade cjc 1295 w dac (GHRH tetra-substituted derivative with DAC) is synthesized via solid-phase peptide synthesis (SPPS):

Attribute	Analytical Specification
Product Name	CJC-1295 with DAC / CJC 1295 w DAC
CAS Registry Number	863288-34-0
Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH₂
Molecular Formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight	3647.28 g/mol
Purity Grade	≥99.0% (Verified via HPLC & Mass Spectrometry)
Physical Appearance	Sterile, white lyophilized cake / powder
Reconstitution Fluid	Bacteriostatic Water or Sterile 0.9% Sodium Chloride
Storage (Unopened)	Store desiccated at -20°C (protected from light)

Mechanism of Action & CJC Peptides Research Applications

In growth factor and neuroendocrine literature, cjc1295 with dac operates through specific physiological receptor mechanisms:

• Extended Albumin Binding: The addition of the Drug Affinity Complex (DAC) allows cjc 1295 w dac to bind spontaneously to circulating serum albumin after exposure. This modification protects the reactive peptide sequence from dipeptidyl peptidase-4 (DPP-IV) cleavage.

• Sustained Pituitary Stimulation: Unlike short-acting GHRH derivatives (such as CJC-1295 No DAC / Mod GRF 1-29), cjc1295 with dac produces a prolonged, baseline elevation in plasma growth hormone and Insulin-like Growth Factor 1 (IGF-1) levels over extended sampling intervals.

• GHS Secretagogue Synergy: Researchers frequently evaluate cjc peptides in combination with ghrelin receptor agonists (GHRPs such as GHRP-2, GHRP-6, or Ipamorelin) to study the synergistic amplification of total pituitary GH release.

Reconstitution & Handling Protocols

To maintain structural stability and preserve peptide activity during experimental setup:

1. Equilibration: Allow the lyophilized cjc 1295 w dac container to adjust to room temperature before inserting a needle to minimize internal condensation.

2. Reconstitution: Using a sterile syringe, direct 1 ml or 2 ml of Bacteriostatic Water slowly down the interior glass wall of the vial.

3. Dissolution: Swirl the vial gently in a circular motion until the lyophilized cake dissolves completely into a clear solution. Do not shake forcefully, as mechanical agitation can shear fragile peptide bonds.

4. Storage: Keep reconstituted liquid stored between 2°C and 8°C. For long-term preservation of stock solutions, store aliquots at -20°C to avoid repeated freeze-thaw cycles.

Frequently Asked Questions

What is the main difference between CJC 1295 w DAC and CJC 1295 No DAC?

CJC 1295 w DAC includes the Drug Affinity Complex extension, extending its biological half-life to 6–8 days and causing a sustained release of GH. CJC 1295 No DAC (Mod GRF 1-29) lacks this complex, yielding a short half-life of 30 minutes that mimics natural pulsatile GH release.

What documentation accompanies CJC peptides when ordered?

Every batch includes access to a lot-specific Certificate of Analysis (COA) displaying High-Performance Liquid Chromatography (HPLC) traces verifying ≥99% purity and Mass Spectrometry (MS) confirming the molecular mass of 3647.28 g/mol.

How should unopened CJC 1295 w DAC vials be stored?

Unopened vials of lyophilized cjc 1295 w dac should be stored in a dry, refrigerated environment between 2°C and 8°C for short-term shelf preservation, or frozen at -20°C for long-term stability.