Premium YK11 SARM (Myostine) – UK Research Grade

If your research facility is searching for certified yk11 sarm inventory for selective androgen receptor assays or myostatin inhibition models, our domestic supply provides reference-grade material. Chemically designated as Myostine, YK-11 is a unique steroidal Selective Androgen Receptor Modulator (SARM) widely investigated for its dual-action profile: selective androgen receptor partial agonism combined with gene-selective upregulation of follistatin.

When sourcing yk11 for sale for laboratory research, chemical purity and batch consistency are essential. Our catalog delivers 99% or greater HPLC-verified purity, complete batch analytical documentation, and fast domestic UK tracked shipping.

Technical Specifications & Chemical Profile

Our reference-grade yk11 sarm reference material is synthesized in strict compliance with laboratory analytical standards:

Attribute	Analytical Specification
Chemical Name	YK-11 / YK11 / Myostine
IUPAC Name	methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2′-methoxy-2′,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5′-1,3-dioxolane]-4′-ylidene]acetate
CAS Registry Number	1370003-76-1
Molecular Formula	C25H34O6
Molecular Weight	430.53 g/mol
Purity Grade	>= 99.0% (Verified via HPLC & Mass Spectrometry)
Physical Form	Fine white to off-white crystalline powder
Solubility Profile	Soluble in DMSO (>20 mg/mL) and Ethanol; insoluble in water
Storage (Unopened)	Store desiccated at -20 degrees C (protected from direct light exposure)

Mechanism of Action & Research Applications

In biochemical and musculoskeletal literature, YK11 is distinguished by its unique molecular mechanism compared to non-steroidal SARMs:

• Steroidal SARM Architecture: Unlike non-steroidal SARMs (such as Ostarine or LGD-4033), yk11 sarm features a synthetic steroidal backbone structurally related to 19-nortestosterone derivative pathways.

• Follistatin Expression Upregulation: In myogenic tissue assays, exposure to YK-11 stimulates significant production of follistatin—an autocrine glycoprotein that acts as an endogenous myostatin inhibitor.

• Myostatin Antagonism: By inducing follistatin expression, YK11 indirectly limits the activity of myostatin (a negative regulator of muscle growth), making it a high-value reference compound in muscle wasting and cachexia signaling models.

• Partial Androgen Receptor Agonism: YK11 binds to the androgen receptor and induces gene expression without dependent N/C terminal AR interaction, displaying gene-selective transcriptional pathways.

Laboratory Handling & Preparation Guidelines

To preserve compound stability and maintain accurate concentration during trial protocols:

1. Equilibration: Allow frozen vials of yk11 sarm to reach ambient room temperature before unsealing to prevent atmospheric moisture condensation.

2. Solubilization: YK-11 is hydrophobic and insoluble in aqueous media. Dissolve raw reference powder in organic laboratory solvents such as high-purity DMSO or absolute ethanol.

3. Agitation: Gentle vortexing or mild warm water bath heating (below 35 degrees C) can accelerate complete dissolution in target solvents.

4. Storage Conditions: Store liquid stock solutions frozen at -20 degrees C in light-protected glass containers. Avoid repeated freeze-thaw cycles.

Frequently Asked Questions

Is YK-11 approved for human or therapeutic use?

No. YK11 SARM is an unapproved investigational research chemical intended strictly for laboratory analytical testing and scientific research. It is not an approved dietary supplement, health product, or human medication.

What analytical documentation accompanies YK11 orders?

Every batch includes access to a lot-specific Certificate of Analysis (COA) detailing High-Performance Liquid Chromatography (HPLC) chromatograms confirming 99% or greater purity, alongside Mass Spectrometry (MS) identity verification.

How should raw YK11 powder be stored long-term?

Store raw, dry yk11 sarm chemical reference powder sealed under desiccated conditions at -20 degrees C in a dark environment