Premium TB 500 Peptide (10mg) – UK Research Grade

If your laboratory facility is looking to buy tb 500 for cell motility, tissue repair, or angiogenesis research, our domestic inventory provides high-purity TB 500 peptide UK stock. As a synthetic derivative of the active region of Thymosin Beta-4 (specifically the LKKTETQ active site sequence), this widely studied 43-amino-acid peptide plays a central role in actin sequestration, cell migration, and dermal wound healing models.

Whether investigating tendon regeneration, cardiovascular tissue repair, or anti-inflammatory signaling pathways, our reference-grade Buy TB 500 supply delivers guaranteed ≥99% HPLC-verified chemical purity, full batch documentation, and fast UK domestic dispatch.

Technical Specifications & Chemical Profile

Our reference-grade TB 500 peptide (Thymosin Beta-4 synthetic sequence) is manufactured under strict solid-phase peptide synthesis (SPPS) standards:

Attribute	Analytical Specification
Product Name	TB-500 / TB 500 (Thymosin Beta-4 active fragment)
CAS Registry Number	77591-33-4 / 885340-86-7
Sequence	Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight	4963.5 g/mol
Purity Grade	≥99.0% (Verified via HPLC & Mass Spectrometry)
Physical Appearance	Sterile, white lyophilized cake / powder
Reconstitution Fluid	Bacteriostatic Water or Sterile 0.9% Sodium Chloride
Storage (Unopened)	Store desiccated at -20°C (protected from UV light)

Mechanism of Action & TB 500 Research Applications

In regenerative biology and cell tissue literature, TB 500 is studied for its ability to regulate cell cytoskeleton dynamics through actin regulation:

• Actin Sequestration & Cell Motility: The primary biological mechanism of the TB 500 peptide involves binding to G-actin, inhibiting actin polymerization and maintaining a pool of actin monomers necessary for rapid cellular migration and wound closure.

• Angiogenesis & Microvascular Growth: Research demonstrates that Buy TB 500 promotes endothelial cell differentiation and neo-vascularization (formation of new blood vessels), supplying crucial oxygen and nutrients to damaged tissues.

• Inflammatory Modulation: Studies highlight the peptide’s capacity to reduce inflammatory cytokine expression in injured tissues, mitigating scar tissue formation (fibrosis) in collagenous repair models such as tendons and ligaments.

Reconstitution & Handling Protocols

To preserve the biological activity and secondary structure of the TB 500 peptide during experimental preparation:

1. Equilibration: Allow the lyophilized Buy TB 500 vial to adjust to room temperature prior to introducing a needle to prevent atmospheric condensation inside the vial.

2. Reconstitution: Using a sterile syringe, direct 1 ml or 2 ml of Bacteriostatic Water slowly against the inner glass wall of the container.

3. Dissolution: Swirl the vial gently in a circular motion until the lyophilized cake is fully dissolved into a clear liquid. Do not shake forcefully, as mechanical agitation can disrupt protein bonds.

4. Storage: Keep reconstituted liquid stored between 2°C and 8°C. For extended preservation of stock solutions, store aliquots at -20°C to avoid repeated freeze-thaw cycles.

Frequently Asked Questions

What is the difference between TB 500 and full-length Thymosin Beta-4?

TB 500 is the synthetic sequence corresponding to the active domain (LKKTETQ) of the naturally occurring Thymosin Beta-4 protein. While possessing similar cellular signaling capabilities, TB 500 is engineered as a low-molecular-weight sequence optimized for laboratory research.

What documentation is provided when I buy TB 500 online?

Every order includes access to a lot-specific Certificate of Analysis (COA) displaying High-Performance Liquid Chromatography (HPLC) traces verifying ≥99% purity and Mass Spectrometry (MS) confirming the molecular mass of 4963.5 g/mol.

How should unopened TB 500 vials be stored?

Unopened vials of lyophilized TB 500 peptide UK stock should be stored in a dry, refrigerated environment between 2°C and 8°C for short-term preservation, or frozen at -20°C for long-term stability.