Premium Ligandrol (LGD-4033) – UK Research Grade

If your scientific facility or laboratory is looking to buy ligandrol stock for selective androgen receptor assays, tissue-selective anabolic signaling, or bone mineral density research models, our domestic supply provides reference-grade materials. Chemically designated as Ligandrol or LGD-4033, this compound is one of the most thoroughly evaluated non-steroidal Selective Androgen Receptor Modulators (SARMs) in preclinical and clinical literature.

When researchers need to buy lgd 4033 for quantitative trial protocols, analytical compound purity and batch traceably are critical. Our inventory to buy lgd-4033 delivers 99% or greater HPLC-verified chemical purity, full batch analytical documentation, and rapid domestic UK tracked dispatch.

Technical Specifications & Chemical Profile

Our reference-grade Ligandrol (LGD-4033) chemical reference material is synthesized in strict compliance with analytical laboratory standards:

Attribute	Analytical Specification
Chemical Name	LGD-4033 / Ligandrol (VK2735 / LGD 4033)
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Registry Number	1165910-22-4
Molecular Formula	C14H12F6N2O
Molecular Weight	338.25 g/mol
Purity Grade	>= 99.0% (Verified via HPLC & Mass Spectrometry)
Physical Form	Fine white to off-white crystalline powder
Solubility Profile	Soluble in DMSO (>30 mg/mL) and Ethanol; insoluble in water
Storage (Unopened)	Store desiccated at -20 degrees C (protected from direct light exposure)

Mechanism of Action & Research Applications

In musculoskeletal and androgenic literature, Ligandrol demonstrates tissue-selective nuclear receptor interactions:

• High-Affinity AR Binding: The compound LGD-4033 binds to the androgen receptor (AR) with high affinity (Ki approx 1 nM), acting as a potent full agonist in muscle and bone tissue while displaying minimal androgenic activity in secondary tissues.

• Anabolic Skeletal Muscle Signaling: Preclinical models show that exposure to Ligandrol stimulates fractional protein synthesis and muscle tissue preservation without typical steroidal side-effect profiles.

• Bone Mineral Density Support: Investigators utilize lgd 4033 to analyze trabecular bone formation and osteoblast activation in osteopenia and bone loss models.

• Selective Anabolic Profile: Designed to resist conversion via 5-alpha reductase or aromatase enzymatic pathways, preventing androgenic or estrogenic cross-reactivity.

Laboratory Handling & Preparation Guidelines

To preserve compound stability and maintain accurate concentration during trial protocols:

1. Equilibration: Allow refrigerated or frozen vials of LGD-4033 reference material to reach ambient room temperature before opening to avoid atmospheric moisture absorption.

2. Solubilization: Ligandrol is hydrophobic and practically insoluble in aqueous solutions. Dissolve raw reference powder in organic carriers like high-purity DMSO or absolute ethanol.

3. Agitation: Gentle vortexing or mild warm water bath heating (below 35 degrees C) accelerates full dissolution in target organic carriers.

4. Storage Conditions: Store liquid stock solutions frozen at -20 degrees C in light-protected glass vials. Avoid repeated freeze-thaw cycles.

Frequently Asked Questions

Is Ligandrol approved for human consumption or therapeutic use?

No. Ligandrol (LGD-4033) is an unapproved investigational research chemical intended strictly for laboratory analytical testing and scientific studies. It is not approved for human or veterinary consumption, medical treatment, or dietary supplement use.

How does LGD-4033 differ from non-steroidal SARMs like Ostarine?

While both are non-steroidal SARMs, LGD-4033 exhibits a higher binding affinity (Ki approx 1 nM) for androgen receptors compared to MK-2866, making it a primary reference standard for high-potency receptor ligand assays.

What analytical documentation accompanies orders when I buy LGD-4033?

Every batch includes access to a lot-specific Certificate of Analysis (COA) containing High-Performance Liquid Chromatography (HPLC) chromatograms confirming 99% or greater purity, alongside Mass Spectrometry (MS) identity verification.