Premium LGD-4033 (Ligandrol) – UK Research Grade

If your laboratory facility is seeking high-purity lgd-4033 for selective androgen receptor pathways or muscle wasting research models, our inventory delivers certified reference-grade material. Chemically designated as Ligandrol, lgd 4033 is one of the most widely studied non-steroidal Selective Androgen Receptor Modulators (SARMs), evaluated in cellular and animal biology for its affinity to tissue-specific androgen receptors.

Whether investigating bone mineral density restoration, anabolic signaling pathways, or lean muscle tissue preservation, our 4033 lgd inventory provides $\ge 99\%$ HPLC-verified chemical purity, complete batch analytical documentation, and fast domestic UK tracked shipping.

Technical Specifications & Chemical Profile

Our reference-grade lgd-4033 (lgd 4033) chemical reference material is synthesized in strict compliance with analytical laboratory standards:

Attribute	Analytical Specification
Chemical Name	LGD-4033 / Ligandrol (VK2735 / LGD 4033)
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Registry Number	1165910-22-4
Molecular Formula	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Molecular Weight	338.25 g/moL
Purity Grade	>= 99.0% (Verified via HPLC & Mass Spectrometry)
Physical Form	Fine white to off-white crystalline powder
Solubility Profile	Soluble in DMSO (>30 mg/mL) and Ethanol; insoluble in water
Storage (Unopened)	Store desiccated at -20^C (protected from light exposure)

Mechanism of Action & Research Applications

In androgenic and musculoskeletal literature, lgd 4033 exhibits clear tissue-selective receptor interactions:

• High-Affinity Receptor Binding: The compound lgd-4033 binds to androgen receptors (AR) with high affinity ($\text{K}_i \approx 1 \text{ nM}$), functioning as a full agonist in muscle and bone tissue while displaying reduced activity in secondary sexual tissues.

• Skeletal Muscle Anabolism: In pre-clinical and clinical trial models, 4033 lgd has demonstrated significant stimulation of muscle tissue hypertrophy and fractional protein synthesis without typical steroidal side-effect profiles on the prostate.

• Bone Mineral Density Interactions: Research demonstrates that exposure to lgd 4033 supports osteoblast activity and trabecular bone formation, making it a key reference compound in osteopenia and osteoporosis models.

Laboratory Handling & Preparation Guidelines

To preserve chemical stability and ensure accurate concentration during experimental protocol setup:

1. Equilibration: Allow frozen containers of lgd-4033 to reach ambient room temperature before opening to avoid atmospheric moisture absorption.

2. Solubilization: LGD-4033 is hydrophobic and insoluble in water. Dissolve raw powder in organic solvents such as high-purity DMSO, PEG 400, or absolute ethanol.

3. Agitation: Gentle vortexing or mild heating ($<40^\circ\text{C}$) in a warm water bath can accelerate full dissolution in stock solvents.

4. Storage Conditions: Store liquid stock solutions frozen at $-20^\circ\text{C}$ in light-protected glass containers. Avoid repeated freeze-thaw cycles.

Frequently Asked Questions

Is LGD-4033 approved for human or clinical consumption?

No. LGD-4033 (Ligandrol) is an unapproved investigational compound intended strictly for laboratory research and analytical testing. It is not an approved dietary supplement or medication.

What analytical documentation accompanies LGD-4033 orders?

Every batch includes a lot-specific Certificate of Analysis (COA) containing High-Performance Liquid Chromatography (HPLC) chromatograms verifying $\ge 99\%$ purity and Mass Spectrometry (MS) identity confirmation.

How should raw LGD-4033 powder be stored long-term?

Store dry, raw lgd 4033 chemical reference powder sealed under desiccated conditions at $-20^\circ\text{C}$ in a dark environment.